APOE Test Could Help Detect Alzheimer’s Risk Years In Advance, Says Doctor

In a recent video on Instagram, longevity expert Dr Vass urged individuals to act early when it comes to brain health.

Trained at Cornell University, Dr Vass explained that the APOE Genotype Test can help identify the risk of Alzheimer’s disease long before any symptoms appear. He noted that memory loss often begins decades before signs become noticeable.

What Is the APOE Genotype Test?

The APOE Genotype Test identifies genetic variations that impact how efficiently the brain clears amyloid-beta proteins.

These sticky plaques are commonly associated with Alzheimer’s disease.

According to the World Health Organisation, Alzheimer’s accounts for up to 70% of all dementia cases.

Dr Vass highlighted the three common variants of the APOE gene, APOE2, APOE3, and APOE4. While APOE2 may offer some protection, APOE4 significantly increases risk. One copy of APOE4 may double or triple the risk, while carrying two copies can raise it up to twelvefold.

“Your brain health starts decades before any memory loss is evident,” Dr Vass stressed in an Instagram post on July 23. He urged people not to wait for symptoms to emerge. Early testing, he said, can serve as a roadmap, not a diagnosis. It allows individuals to take control of their health through targeted lifestyle changes.

 

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A post shared by Dr. Vass, M.D. (@dr.vassily)

Beyond the APOE gene, Dr Vass advised checking other health indicators such as,

• Fasting insulin (linked to brain shrinkage)
• Homocysteine (associated with brain atrophy)
• CRP and omega-3 levels (markers for inflammation and brain health)

These tests can provide a broader understanding of one’s cognitive risk profile.

For those with a high-risk APOE genotype, Dr Vass recommended several evidence-backed interventions.

• A low-glycaemic, anti-inflammatory diet rich in polyphenols like blueberries
• Regular Zone 2 cardio and strength training, known to support hippocampal growth
• At least 7.5 hours of sleep nightly to support the brain’s detox process
• Consideration of mitochondrial cognitive peptides under expert guidance

Dr Vass concluded that while genetics may increase risk, lifestyle choices can strongly influence outcomes. “Even if you carry the APOE4 gene, you can take control,” he wrote. By testing early and acting on the results, people can significantly improve their chances of maintaining cognitive health well into old age.

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