A scientist who researches weight control found that most people gain weight because of their sense of taste. It should be noted that we stop eating as soon as we start to feel full. For many years, experts believed that signals from the stomach and intestines to the brain were the only sources of this change in speed. However, as evidenced by a recent study, there is also another process in action, and it starts as soon as we taste our food.
Because it has not been possible for humans to see the crucial brain activity in an animal during feeding, this mechanism has remained unknown until recently. Deep within the brainstem are the neurons in question. It wasn’t until a graduate student created new methods that people could see these neurons’ activity.
Our eating is regulated by two independent neural pathways: one sets a time limit for eating and the other sets a quantity limit. Food’s flavor triggers the first route. It may seem paradoxical, yet we often prefer to consume more delicious food. But taste also regulates how quickly we consume, even though we might not be aware of it.
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This first pathway, as scientists have long thought, involves signals from the gut, but our study shows that those cues may also be overridden when the brain receives signals from taste receptors in the mouth, saying “There’s food here.” Scientists are working on figuring out how this sensory filtering works, in an effort to uncover new strategies for treating obesity.
Scientists have found that neurons in the second circuit they studied, which controls appetite restriction, do so by secreting the hormone GLP-1, which produces a sustained feeling of fullness. Novel obesity medications like Mounjaro and Ozempic imitate GLP-1’s actions. A group of scientists is currently working to comprehend the mechanism underlying this long-lasting satiety in order to better comprehend these novel medications and maybe find novel approaches to weight control.
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