India

Key Discovery In Immune Response System Made By IIT Kanpur Scientists

A molecular mechanism of complement receptor activation and signalling, which is a vital part of our immune response have been discovered by a team of scientists led by Prof Arun Shukla at IIT Kanpur today.

The team carried out their research based on the complement system and its dependence on molecules called anaphylatoxins, like C3a and C5a, which interact with specific receptors known as C3aR and C5aR1. How the receptors work and recognize their targets, activate, and control signalling were tried to be understand which remained a mystery so far.

Also Read :    Ibrahim Ousted As JD(S) K’taka Chief. Kumaraswami Takes Over

The scientists  used a powerful imaging technique called cryo-EM in the study to reveal the inner workings of these receptors when they are activated by natural and synthetic compounds. They have discovered unique binding pockets where anaphylatoxins attach to these receptors, shedding light on how the receptors become activated and engage with signalling proteins.

Apart from this, the study also uncovered a natural mechanism where C5a’s inflammatory response is reduced through the removal of a specific part of the molecule. It also identified a peptide that selectively activates C3aR, demonstrating that the receptors can respond differently to various compounds.

Also Read :   Big Blow To Uddhav Thackeray. Here’s How

This research also provides a clearer understanding of how anaphylatoxin receptors function, which are important drug targets for inflammatory disorders like arthritis, asthma, sepsis, and many other disorders.  A great chance has evolved for the discovery of medicines for several diseases.

Debajit Kar

Recent Posts

Delhi Pollution: SC Orders Action On GRAP Violations, Directs Relief For Affected Workers

The SC on Monday instructed CAQM to act against officers and entities failing to enforce…

2 hours ago

IPL 2025 Auction: 13-Year-Old Vaibhav Suryavanshi Becomes Youngest Player Signed

Rajasthan Royals (RR) secured Vaibhav Suryavanshi for Rs 1.10 crore at the Abadi Al Johar…

3 hours ago

Islamabad Tense As Security Forces Brace For Clash With PTI Supporters Demanding Imran Khan’s Release

Pakistan Tehreek-e-Insaf’s (PTI) ‘Final Call’ protest rally, led by Bushra Bibi, has reached outskirts of…

4 hours ago

IPL 2025 Auction: Gujarat Titans Sign Sherfane Rutherford For Rs 2.6 Cr, KKR Add Manish Pandey For Rs 75 Lakh

The Gujarat Titans (GT) secured West Indies batter Sherfane Rutherford for Rs 2.6 crore during…

4 hours ago

IPL 2025 Auction: Bhuvneshwar Kumar Headlines Day 2 With Rs 10.75 Crore Move To RCB

Bhuvneshwar Kumar stole the spotlight on Day 2 of the IPL 2025 Auction. Royal Challengers…

6 hours ago

Self-Help Groups To Provide Ganga Water To Pilgrims At Maha Kumbh 2025

Maha Kumbh 2025 will combine spirituality and women’s empowerment, with self-help groups providing bottled Ganga…

7 hours ago