In a world-first study, Australian researchers have demonstrated the feasibility and safety of using stabilised hyaluronic acid (sHA) gel during radiation treatment for gynaecological cancers.
The findings mark a significant step towards improving treatment precision and patient outcomes in women undergoing cancer care.
Led by experts from Monash University, the study explored the use of sHA gel in women receiving MRI-guided brachytherapy, a form of internal radiation treatment.
Doctors used the gel to gently create additional space between the tumour and the rectum, aiming to reduce radiation exposure to healthy tissue.
By increasing this distance, clinicians were able to better target tumours with higher radiation doses while minimising damage to surrounding organs, potentially leading to more effective and safer treatment.
The small study involved 12 patients, all of whom tolerated the procedure well.
Doctors reported that the gel was easy to apply and clearly visible on MRI scans, allowing accurate monitoring throughout treatment.
Importantly, patients felt no discomfort, and doctors reported no complications related to the gel.
The sHA gel successfully increased the distance between the tumour and the rectum in all participants and remained stable throughout the course of brachytherapy.
Over time, the gel safely dissolves in the body, as already established through its approved use in prostate cancer treatment.
Dr Carminia Lapuz from Monash University said the study highlights promising technical advantages for improving brachytherapy outcomes in gynaecological cancers.
While long-term effects were not assessed, the results confirm that the approach is safe and feasible.
By enabling more precise radiation delivery and reducing exposure to healthy tissue, the use of sHA gel could improve quality of life, reduce long-term side effects, and also contribute to more effective and equitable cancer care for women worldwide.
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